Decline in hypothalamic Menin linked to aging, and supplementation with amino acid may help reverse age-related changes, study finds

A new study in PLOS Biology by Lige Leng of Xiamen University and colleagues suggests that the decline in the hypothalamic protein Menin may play a key role in aging.

The study found that a reduction of Menin in younger mice led to an increase in hypothalamic neuroinflammation, aging-related phenotypes, cognitive decline, and a modestly reduced lifespan.

The authors also found that the decline in Menin levels led to a decline in levels of the amino acid D-serine, which is known to be a neurotransmitter and is sometimes used as a dietary supplement found in soybeans, eggs, fish, and nuts.

However, the study found that dietary supplementation with D-serine may mitigate some age-related changes, such as improving cognition, balance, skin thickness, and bone mass.

Read more: https://neurosciencenews.com/menin-aging-reversal-22808/