New mechanism related to ageing identified, offers hope for improved mobility in older people

Researchers from the University of Helsinki and the Swiss Federal Institute of Technology in Lausanne have identified a new mechanism related to ageing that affects muscle function and reduces mobility in older people.

The mechanism is related to the accumulation of ceramide lipid fatty molecules in muscle tissue, which are involved in cell signaling.

Normally, the amount of muscle tissue decreases, and mobility declines with age. The researchers found that the amount of ceramide and other sphingolipid fatty molecules in muscle tissue increases with age. In tests on mice, reducing ceramide levels improved muscle strength and the ability of stem cells to regenerate muscle tissue.

The researchers then analyzed blood samples from elderly individuals and found that those with a specific genetic trait that reduced ceramide levels had better muscle strength and mobility.

The researchers hope that the discovery will lead to the development of new drugs to improve mobility in older people.

Read more: https://www.verkkouutiset.fi/a/tutkijat-loysivat-uuden-ikaantymisen-mekanismin/#eb2fd2a4